Programme
June 19
15.00 – 19.00 Registration, mounting of posters
19.00 – 19.15 Conference opening
Sergey Razin (Moscow, Russia), Chairman of the 25th Wilhelm Bernhard Workshop Organizing Committee
19.15 – 20.15 Opening Lecture
Yosef Gruenbaum (Jerusalem, Israel) Regulation of nuclear mechanics by the nuclear lamina
20.15 – 22.00 Welcome reception (restaurant, 1floor)
June 20
Workshop I Chromatin structure and dynamics (Part 1)
Chairmen: Gabor Szabo and Elena Gaginskaya
09.00 – 09.35
Kerstin Bystricky (Toulouse, France) Transcription induced chromatin dynamics and reorganization at single gene loci
09.35 – 10.10
Klaus Scherrer (Paris, France) 3D-Genome Organisation, Morphogenesis and Cancer
10.10 – 10.35
Alla Krasikova (Saint-Petersburg, Russia) Three-dimensional genome architecture in chicken somatic and germ cells
10.35 – 11.00
Ildikó Kristó (Szeged, Hungary) The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export
11.00 – 11.30 Coffee break
Workshop I Chromatin structure and dynamics (Part 1) - continuation
Chairmen: Alla Krasikova and Yana Musinova
11.30 – 11.55
Alexander Ishov (Gainesville, USA) CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx
11.55 – 12.20
Christian Schöefer (Vienna, Austria) Visualizing chromatin architecture in nuclei and nucleoli
12.20 – 12.45
Gabor Szabo (Debrecen, Hungary) The effect of histone modifications and DNA superhelicity on nucleosome stability
12.45 – 13.10
Sergey Razin (Moscow, Russia) Organization and evolution of vertebrate globin gene domains
13.10 – 14.00 Lunch
14.00 – 15.00 Poster session I
Announcement of the best poster winners for the Poster session I
Workshop II Nuclear compartmentalization
Chairmen: Yosef Gruenbaum and Alexander Ishov
15.00 – 15.35
Ivan Raska (Prague, Czech Republic) Structure and dynamics of the Polycomb body
15.35 – 16.00
Masahiko Harata (Sendai, Japan) Roles of actin family proteins in the organization of functional structures within the nucleus
16.00 – 16.25
Elena Gaginskaya (Saint-Petersburg, Russia) The nucleolus in avian oogenesis
16.25 – 16.50
Veit Schubert (Gatersleben, Germany) Super-resolution microscopy reveals the ultrastructure of plant nuclei
16.50 – 17.20 Coffee break
Workshop III Nuclear envelope and lamina
Chairman: Ivan Raska and Yana Musinova
17.20 – 17.50
Ryszard Rzepecki (Wrocław, Poland) Analysis of protein complexes containing lamin B – interactions with topo II and with nucleic acids and chromatin in vivo.
17.50 – 18.15
Igor Sharakhov (Tomsk, Russia) Tissue-specific aspects of chromosome-nuclear envelope interactions
19.00 Sightseeing tour of Nizhny Novgorod
June 21
Workshop IV Chromatin Structure and dynamics (Part 2)
Chairmen: Kerstin Bystricky and Eugene Sheval
09.00 – 09.25
Veniamin Fishman (Novosibirsk, Russia) Targeted modification of topological domains in mice
09.25 – 09.50
Alexey Gavrilov (Moscow, Russia) Genome wide mapping of RNA-chromatin interactome in vivo
10.15 – 10.40
Yegor Vassetzky (Villejuif, France) Virus-induced nuclear architecture remodeling in human B-lymphocytes: a key factor in lymphomagenesis?
10.40 – 11.05
Tatyana Zykova (Novosibirsk, Russia) Polytene chromosomes – a portrait of functional organization of the Drosophila genome
11.05 -11.25 Coffee break
Workshop V Nuclear organization and transcription
Chairmen: Yegor Vassetzky and Nikolajs Sjakste
11.25 – 11.50
Pavel Hozak (Prague, Czech Republic) Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient DNA transcription
11.50 – 12.15
Steven Kosak (Chicago, USA) Genetic polarity: the concomitant positioning of gene loci and the functional distribution of their encoded proteins
12.15 – 12.40
Paul Schedl (Princeton, USA) Drosophila dosage compensation: drawing connections between the chromatin entry sites (CES) for the MSL dosage compensation machinery and chromatin boundaries
12.40-12.50 Best poster presentation I
12.50-13.00 Best poster presentation I
13.00 – 14.00 Lunch
14.00 – 15.00 Poster session II
Announcement of the best poster winners for the Poster session II
Satellite meeting: Molecular and cellular events in human diseases
Chairmen: Marc Mirande and Olga Lavrik
15.00 – 15.20
Svetlana Dokudovskaya (Villejuif, France) Regulation of the mTORC1 pathway
15.20 – 15.40
Anna Smirnova (Novosibirsk, Russia) The study of activation effects of HIF transcription factor on the potential of endothelial angiogenic derivatives in human pluripotent stem cells
15.40. – 16.00
Ekaterina Belousova (Novosibirsk, Russia) The new acceptors of PARP family proteins
16.00 – 16.20
Iryna Tykhonkova (Kiev, Ukraine) Phospho-mTOR (Ser2481) associated with chromosomes during metaphase
16.20 – 16.50 Coffee break
Chairmen: Lev Ovchinnikov and Alexander Ishchenko
16.50 – 17.10
Oleg Demidov (Dijon, France) A role of nuclear DDR-regulating phosphatase PP2Cdelta in modulation of tumor microenvironment and tumor resistance to chemotherapy
17.10 – 17.30
Marc Mirande (Gif-sur-Yvette, France) Viral hijacking of translational components required for HIV-1 replication
17.30 – 17.50
Bakhyt Matkarimov (Astana, Kazakhstan) Analysis of NCBI dbSNP big data
17.50 – 18.10
Elizaveta Alemasova (Novosibirsk, Russia) Production and purification of recombinant analog of Y-box binding protein
18.10 – 20.00 Meeting of the WBW International committee
18.10 – 20.00 Meeting of the GDRI committee.
June 22
Workshop VI DNA replication and repair
Chairmen: Sergey Razin and Olga Iarovaia
09.00 – 09.25
Olga Lavrik (Novosibirsk, Russia) Protein-protein interactions operating in base excision DNA repair
09.25 – 09.50
Nadezhda Rechkunova (Novosibirsk, Russia) Protein poly(ADP-ribosyl)ation by PARP1 as the regulating mechanism in nucleotide excision repair
09.50 – 10.15
Mikhail Klenov (Moscow, Russia) Role of piRNA system in transcriptional regulation of transposable elements and ribosomal RNA.
10.15 – 10.40
Alena Makarova (Moscow, Russia) The mechanism of the dRP-lyase activity of human DNA polymerase iota
10.40 – 11.10 Coffee break
11.10 – 11.35
Joao Matos (Zürich, Switzerland) A mechanism for controlled breakage of under-replicated chromosomes during mitosis
11.35 – 12.00
Alexander Ishchenko (Villejuif, France) Poly(ADP-ribose) polymerase 3 mono(ADPribosyl)ate DNA termini at double-strand DNA breaks
12.00 – 12.10 Best poster presentation II
12.10 – 12.20 Best poster presentation II
12.20 – 13.30 Lunch
Workshop VII Nuclear organization and disease
Chairmen: Pavel Hozak and Iryna Tykhonkova
13.30 – 14.15
WBW Young investigator award lecture Massimo Lopes (Zurich, Switzerland) Replication fork remodeling: a double-edged sword in genome stability and cancer therapy
14.15 – 14.40
Nick Barlev (Leicester, UK) Functional interaction between Lysine Methyltransferase Set7/9 and the RNA processing protein Sam68 controls its cellular localization and is required for p53 activity
14.40 – 15.05
Lev Ovchinnikov (Puschino, Russia) The Y-box binding protein 1 (YB-1) as a potential remedy for Alzheimer's disease
15.05 – 15.20
Diego Germini (Villejuif, France) HIV-1 protein Tat induces ROS production leading to genomic instability. A possible explanation to the B cell malignancies in AIDS patients
15.20 – 15.45
Nikolajs Sjakste (Riga, Latvia) Parameters of nitric oxide metabolism and DNA integrity in patients with autoimmune diseases
15.45 – 16.10
Ildikó Kristó (Szeged, Hungary) The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export
16.10 Closure of the meeting - announcement of the venue for the WBW XXVI
18.00 - 22.00 Gala dinner on a boat*
*Please note that it would be impossible to leave the boat until 22:00, so please arrange your travel plans accordingly
June 23
Departure
15.00 – 19.00 Registration, mounting of posters
19.00 – 19.15 Conference opening
Sergey Razin (Moscow, Russia), Chairman of the 25th Wilhelm Bernhard Workshop Organizing Committee
19.15 – 20.15 Opening Lecture
Yosef Gruenbaum (Jerusalem, Israel) Regulation of nuclear mechanics by the nuclear lamina
20.15 – 22.00 Welcome reception (restaurant, 1floor)
June 20
Workshop I Chromatin structure and dynamics (Part 1)
Chairmen: Gabor Szabo and Elena Gaginskaya
09.00 – 09.35
Kerstin Bystricky (Toulouse, France) Transcription induced chromatin dynamics and reorganization at single gene loci
09.35 – 10.10
Klaus Scherrer (Paris, France) 3D-Genome Organisation, Morphogenesis and Cancer
10.10 – 10.35
Alla Krasikova (Saint-Petersburg, Russia) Three-dimensional genome architecture in chicken somatic and germ cells
10.35 – 11.00
Ildikó Kristó (Szeged, Hungary) The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export
11.00 – 11.30 Coffee break
Workshop I Chromatin structure and dynamics (Part 1) - continuation
Chairmen: Alla Krasikova and Yana Musinova
11.30 – 11.55
Alexander Ishov (Gainesville, USA) CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx
11.55 – 12.20
Christian Schöefer (Vienna, Austria) Visualizing chromatin architecture in nuclei and nucleoli
12.20 – 12.45
Gabor Szabo (Debrecen, Hungary) The effect of histone modifications and DNA superhelicity on nucleosome stability
12.45 – 13.10
Sergey Razin (Moscow, Russia) Organization and evolution of vertebrate globin gene domains
13.10 – 14.00 Lunch
14.00 – 15.00 Poster session I
Announcement of the best poster winners for the Poster session I
Workshop II Nuclear compartmentalization
Chairmen: Yosef Gruenbaum and Alexander Ishov
15.00 – 15.35
Ivan Raska (Prague, Czech Republic) Structure and dynamics of the Polycomb body
15.35 – 16.00
Masahiko Harata (Sendai, Japan) Roles of actin family proteins in the organization of functional structures within the nucleus
16.00 – 16.25
Elena Gaginskaya (Saint-Petersburg, Russia) The nucleolus in avian oogenesis
16.25 – 16.50
Veit Schubert (Gatersleben, Germany) Super-resolution microscopy reveals the ultrastructure of plant nuclei
16.50 – 17.20 Coffee break
Workshop III Nuclear envelope and lamina
Chairman: Ivan Raska and Yana Musinova
17.20 – 17.50
Ryszard Rzepecki (Wrocław, Poland) Analysis of protein complexes containing lamin B – interactions with topo II and with nucleic acids and chromatin in vivo.
17.50 – 18.15
Igor Sharakhov (Tomsk, Russia) Tissue-specific aspects of chromosome-nuclear envelope interactions
19.00 Sightseeing tour of Nizhny Novgorod
June 21
Workshop IV Chromatin Structure and dynamics (Part 2)
Chairmen: Kerstin Bystricky and Eugene Sheval
09.00 – 09.25
Veniamin Fishman (Novosibirsk, Russia) Targeted modification of topological domains in mice
09.25 – 09.50
Alexey Gavrilov (Moscow, Russia) Genome wide mapping of RNA-chromatin interactome in vivo
10.15 – 10.40
Yegor Vassetzky (Villejuif, France) Virus-induced nuclear architecture remodeling in human B-lymphocytes: a key factor in lymphomagenesis?
10.40 – 11.05
Tatyana Zykova (Novosibirsk, Russia) Polytene chromosomes – a portrait of functional organization of the Drosophila genome
11.05 -11.25 Coffee break
Workshop V Nuclear organization and transcription
Chairmen: Yegor Vassetzky and Nikolajs Sjakste
11.25 – 11.50
Pavel Hozak (Prague, Czech Republic) Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient DNA transcription
11.50 – 12.15
Steven Kosak (Chicago, USA) Genetic polarity: the concomitant positioning of gene loci and the functional distribution of their encoded proteins
12.15 – 12.40
Paul Schedl (Princeton, USA) Drosophila dosage compensation: drawing connections between the chromatin entry sites (CES) for the MSL dosage compensation machinery and chromatin boundaries
12.40-12.50 Best poster presentation I
12.50-13.00 Best poster presentation I
13.00 – 14.00 Lunch
14.00 – 15.00 Poster session II
Announcement of the best poster winners for the Poster session II
Satellite meeting: Molecular and cellular events in human diseases
Chairmen: Marc Mirande and Olga Lavrik
15.00 – 15.20
Svetlana Dokudovskaya (Villejuif, France) Regulation of the mTORC1 pathway
15.20 – 15.40
Anna Smirnova (Novosibirsk, Russia) The study of activation effects of HIF transcription factor on the potential of endothelial angiogenic derivatives in human pluripotent stem cells
15.40. – 16.00
Ekaterina Belousova (Novosibirsk, Russia) The new acceptors of PARP family proteins
16.00 – 16.20
Iryna Tykhonkova (Kiev, Ukraine) Phospho-mTOR (Ser2481) associated with chromosomes during metaphase
16.20 – 16.50 Coffee break
Chairmen: Lev Ovchinnikov and Alexander Ishchenko
16.50 – 17.10
Oleg Demidov (Dijon, France) A role of nuclear DDR-regulating phosphatase PP2Cdelta in modulation of tumor microenvironment and tumor resistance to chemotherapy
17.10 – 17.30
Marc Mirande (Gif-sur-Yvette, France) Viral hijacking of translational components required for HIV-1 replication
17.30 – 17.50
Bakhyt Matkarimov (Astana, Kazakhstan) Analysis of NCBI dbSNP big data
17.50 – 18.10
Elizaveta Alemasova (Novosibirsk, Russia) Production and purification of recombinant analog of Y-box binding protein
18.10 – 20.00 Meeting of the WBW International committee
18.10 – 20.00 Meeting of the GDRI committee.
June 22
Workshop VI DNA replication and repair
Chairmen: Sergey Razin and Olga Iarovaia
09.00 – 09.25
Olga Lavrik (Novosibirsk, Russia) Protein-protein interactions operating in base excision DNA repair
09.25 – 09.50
Nadezhda Rechkunova (Novosibirsk, Russia) Protein poly(ADP-ribosyl)ation by PARP1 as the regulating mechanism in nucleotide excision repair
09.50 – 10.15
Mikhail Klenov (Moscow, Russia) Role of piRNA system in transcriptional regulation of transposable elements and ribosomal RNA.
10.15 – 10.40
Alena Makarova (Moscow, Russia) The mechanism of the dRP-lyase activity of human DNA polymerase iota
10.40 – 11.10 Coffee break
11.10 – 11.35
Joao Matos (Zürich, Switzerland) A mechanism for controlled breakage of under-replicated chromosomes during mitosis
11.35 – 12.00
Alexander Ishchenko (Villejuif, France) Poly(ADP-ribose) polymerase 3 mono(ADPribosyl)ate DNA termini at double-strand DNA breaks
12.00 – 12.10 Best poster presentation II
12.10 – 12.20 Best poster presentation II
12.20 – 13.30 Lunch
Workshop VII Nuclear organization and disease
Chairmen: Pavel Hozak and Iryna Tykhonkova
13.30 – 14.15
WBW Young investigator award lecture Massimo Lopes (Zurich, Switzerland) Replication fork remodeling: a double-edged sword in genome stability and cancer therapy
14.15 – 14.40
Nick Barlev (Leicester, UK) Functional interaction between Lysine Methyltransferase Set7/9 and the RNA processing protein Sam68 controls its cellular localization and is required for p53 activity
14.40 – 15.05
Lev Ovchinnikov (Puschino, Russia) The Y-box binding protein 1 (YB-1) as a potential remedy for Alzheimer's disease
15.05 – 15.20
Diego Germini (Villejuif, France) HIV-1 protein Tat induces ROS production leading to genomic instability. A possible explanation to the B cell malignancies in AIDS patients
15.20 – 15.45
Nikolajs Sjakste (Riga, Latvia) Parameters of nitric oxide metabolism and DNA integrity in patients with autoimmune diseases
15.45 – 16.10
Ildikó Kristó (Szeged, Hungary) The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export
16.10 Closure of the meeting - announcement of the venue for the WBW XXVI
18.00 - 22.00 Gala dinner on a boat*
*Please note that it would be impossible to leave the boat until 22:00, so please arrange your travel plans accordingly
June 23
Departure